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The school sat in limbo
and a transitional period from 1933 to 1939, during which the school’s main building burned and was replaced with the huge building currently occupying the site. In 1939 the Sioux Sanitarium was opened at the location. The facility was created to treat Native Americans with tuberculosis. The building was then converted into a massive hospital called the Sioux Sanitarium for Native American TB patients in 1939. These years were the darkest in the institution's history. With no cure in sight, the doctors could only do experimental procedures such as removing organs to try and combat the disease. After the patenting of streptomycin, the hospital closed in the 1960s.